C‐reactive protein and D‐dimer with clinical probability score in the exclusion of pulmonary embolism
作者： N. Steeghs , R. J. Goekoop , R. W. L. M. Niessen , G. J. P. M. Jonkers , H. Dik
DOI: 10.1111/J.1365-2141.2005.05652.X
关键词:
摘要: This study evaluated the diagnostic value of C-reactive protein (CRP) combined with a clinical decision rule in exclusion pulmonary embolism (PE) and compared this D-dimer. In 363 consecutive outpatients CRP D-dimer test were performed probability PE was assessed. Patients levels or=500 microg/l or indicating 'PE likely'. The had sensitivity 95.7% [95% confidence interval (CI): 90-100] negative predictive (NPV) 98.4% (96-100). CRP<5 mg/l score unlikely' (n=108, 30%), 96.7% (90-100), specificity 43.0% (37-49) NPV 99.1% (97-100). D-dimer<500 (n=170, 51%), 67.9% (62-74) 99.4% (98-100). Based on retrospective data it concluded that standard can potentially be used to safely exclude PE, either as sole assessment. Prospective studies are needed confirm these findings.
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