Evidence for a familial esophageal cancer susceptibility gene on chromosome 13.
作者： Michael R. Emmert-Buck , Carol Giffen , Ti Ding , Alisa M. Goldstein , Nan Hu
DOI:
关键词:
摘要: Previous segregation analyses of pedigrees from areas China where esophageal squamous cell carcinoma (ESCC) rates are extraordinarily high suggested a Mendelian mode transmission. We initiated search for major ESCC gene by conducting genome-wide scan in tumors. Chromosome 13 showed loss heterozygosity (LOH) 95% microsatellite markers, the highest frequency LOH on any chromosome. In current study, we established high-resolution deletion map using 107 markers 13q and compared family history upper gastrointestinal cancer. Overall allelic was significantly higher those with positive (versus negative) history, suggesting presence an inherited tumor suppressor ESCC.
aacrjournals.org参考文章(14)
Michael R Emmert-Buck, Carol Giffen, Sanford M Dawsey, Quan-Hong Wang, Chaoyu Wang, Ti Ding, Alisa M Goldstein, Mark J Roth, Nan Hu, Guang Li, Ze-Zhong Tang, Philip R Taylor, Wen-Jun Li, Jing Huang, Infrequent Mutation in the BRCA2 Gene in Esophageal Squamous Cell Carcinoma Clinical Cancer Research. ,vol. 8, pp. 1121- 1126 ,(2002)
Sheryl Gere, Maxwell P. Lee, H. Shuen Lo, Philip R. Taylor, Hua Su, Ning Lu, Nan Hu, Alisa M. Goldstein, Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma. Cancer Research. ,vol. 62, pp. 4191- 4193 ,(2002)
Nan Hu, Mark J. Roth, Mihael Polymeropolous, Ze-Zhong Tang, Michael R. Emmert-Buck, Quan-Hong Wang, Alisa M. Goldstein, Shou-Shan Feng, Sanford M. Dawsey, Ti Ding, Zheng-Ping Zhuang, Xiao-You Han, Thomas Ried, Carol Giffen, Philip R. Taylor, Identification of novel regions of allelic loss from a genomewide scan of esophageal squamous-cell carcinoma in a high-risk Chinese population. Genes, Chromosomes and Cancer. ,vol. 27, pp. 217- 228 ,(2000) , 10.1002/(SICI)1098-2264(200003)27:3<217::AID-GCC1>3.0.CO;2-A
Allen E. Bale, Alberto Falchetti, Elizabeth Streeten, Mark B. Zimering, Lee S. Weinstein, Wesley O. McBride, Yusuke Nakamura, Maria-Luisa Brandi, Jeffrey A. Norton, Gerald D. Aurbach, Allen M. Spiegel, Stephen J. Marx, Eitan Friedman, Kazushige Sakaguchi, Clonality of Parathyroid Tumors in Familial Multiple Endocrine Neoplasia Type 1 The New England Journal of Medicine. ,vol. 321, pp. 213- 218 ,(1989) , 10.1056/NEJM198907273210402
Jeffrey L. McKeeby, Xiaoming Li, Zhengping Zhuang, Alexander O. Vortmeyer, Steve Huang, Mark Pirner, Monica C. Skarulis, Laura James-Newton, Stephen J. Marx, Irina A. Lubensky, Multiple leiomyomas of the esophagus, lung, and uterus in multiple endocrine neoplasia type 1. American Journal of Pathology. ,vol. 159, pp. 1121- 1127 ,(2001) , 10.1016/S0002-9440(10)61788-9
WANDE GUO, WILLIAM J BLOT, JUN-YAO LI, PHILIP R TAYLOR, BO QI LIU, WEN WANG, YAN PING WU, WEI ZHENG, SANFORD M DAWSEY, BING LI, JOSEPH F FRAUMENI, A Nested Case-Control Study of Oesophageal and Stomach Cancers in the Linxian Nutrition Intervention Trial International Journal of Epidemiology. ,vol. 23, pp. 444- 450 ,(1994) , 10.1093/IJE/23.3.444
N Hu, S.M Dawsey, M Wu, P.R Taylor, Family history of oesophageal cancer in Shanxi Province, China. European Journal of Cancer and Clinical Oncology. ,vol. 27, pp. 1336- ,(1991) , 10.1016/0277-5379(91)90116-U
N HU, S M DAWSEY, M WU, G E BONNEY, L J HE, XY HAN, M FU, P R TAYLOR, Familial Aggregation of Oesophageal Cancer in Yangcheng County, Shanxi Province, China International Journal of Epidemiology. ,vol. 21, pp. 877- 882 ,(1992) , 10.1093/IJE/21.5.877
Michael R. Emmert-Buck, Carol Giffen, Sanford M. Dawsey, Quan-Hong Wang, Xiao-You Han, Ti Ding, Philip R. Taylor, Mark J. Roth, Mihael Polymeropolous, Ze-Zhong Tang, Nan Hu, Alisa M. Goldstein, Allelic Loss in Esophageal Squamous Cell Carcinoma Patients with and without Family History of Upper Gastrointestinal Tract Cancer Clinical Cancer Research. ,vol. 5, pp. 3476- 3482 ,(1999)
Guang Li, Nan Hu, Alisa M. Goldstein, Ze-Zhong Tang, Mark J. Roth, Quan-Hong Wang, Sanford M. Dawsey, Xiao-You Han, Ti Ding, Jing Huang, Carol Giffen, Philip R. Taylor, Michael R. Emmert-Buck, Allelic loss on chromosome bands 13q11-q13 in esophageal squamous cell carcinoma. Genes, Chromosomes and Cancer. ,vol. 31, pp. 390- 397 ,(2001) , 10.1002/GCC.1158