Experimental model of severe renal hypertension.

摘要: A simple technique is described for producing severe reproducible renal hypertension in the rat. Total ligation of aorta between arteries and just below origin superior mesenteric artery resulted sustained systolic diastolic pressures 90 per cent 170 rats studied. Arterial pressure then measured conscious unrestrained rat through a carotid cannula inserted no more than 48 hours before measurements are made. The mean arterial increases to peak 180 mm. Hg at day 5 remains plateau 160 40 days study. Plasma renin but returns baseline 30 despite persistence hypertension. Infarction left kidney aortic constriction results increase or plasma renin. Infarctions right by emboli originating from indwelling associated with greater blood standard preparation. Prolonged cannulation must be avoided order prevent such emboli. This allows studies on pathogenesis an excellent degree reproducibility reliability.