Determinants of survival after liver resection for metastatic colorectal carcinoma.

摘要: PURPOSE Prognostic factors for survival after liver resection metastatic colorectal cancer identified up to date are quite inconsistent with a great inter-study variability. In this study we aimed identify predictors of outcome in our patient population. METHODS A series 70 consecutive patients from the oncological hepatobiliary database, who had undergone curative hepatic surgical metastases origin, operated between 2006 and 2011, were identified. At 44.6 months (range 13.7-73), 30 (42.85%) alive. Patient demographics, primary tumor factors, operative pathologic findings, recurrence patterns, disease-free (DFS), overall (OS) cancer-specific (CSS) analyzed. Clinicopathologic variables tested using univariate multivariate analyses. RESULTS The 3-year CSS first was 54%. Median 40.2 months. second 24.2 DFS 14%. disease free 18 27% median 12 30-day mortality morbidity rate 5.71% 12.78%, respectively. analysis significantly reduced following factors: age >53 years, advanced T stage tumor, moderately- poorly differentiated positive narrow margin, preoperative CEA level >30 ng/ml, <18 Perioperative chemotherapy related metastasectomy showed trend improving (p=0.07). improved statistically significant way (p=0.03). achievement margins beyond 1 mm major determinants both analysis. CONCLUSIONS 1mm perioperative chemotherapy. Studies on larger population analyses additional clinicopathologic like genetic markers could contribute development clinical scoring models assess risk relapse survival.