Doxorubicin Induces ER Calcium Release via Src in Rat Ovarian Follicles.
作者： Aziz Ur Rehman Aziz , Chunyang Geng , Wang Li , Xiaohui Yu , Kai-Rong Qin
关键词:
摘要: Although doxorubicin has been widely used as an anticancer drug, it dose-dependent toxic effects on ovarian follicle development and apoptosis, oocyte maturation, hormone secretion. Ca2+ signaling also vital roles in the same cellular functions of follicles, indicating a strong link with doxorubicin-induced toxicity. In current project, alternations cultured rat follicles have explored fluorescence resonance energy transfer technology. The results reveal that enhances cytosolic level smoothly. Further experiments confirm endoplasmic reticulum (ER) calcium, but not extracellular calcium influx, is main source intracellular increase. Moreover, Src kinase activation could be upstream ER release. Therefore, this project demonstrates increases mainly by releasing from via which provides deeper understanding
oup.com
sci-hub.se 参考文章(55)
F Zorzato, G Salviati, T Facchinetti, P Volpe, Doxorubicin induces calcium release from terminal cisternae of skeletal muscle. A study on isolated sarcoplasmic reticulum and chemically skinned fibers. Journal of Biological Chemistry. ,vol. 260, pp. 7349- 7355 ,(1985) , 10.1016/S0021-9258(17)39615-1
Yanzhou YANG, Yaping JIN, Amanda C MARTYN, Pengfei LIN, Yujie SONG, Fenglei CHEN, Linyong HU, Chenchen CUI, Xiao LI, Qian LI, Ray LU, Aihua WANG, Expression Pattern Implicates a Potential Role for Luman Recruitment Factor in the Process of Implantation in Uteri and Development of Preimplantation Embryos in Mice Journal of Reproduction and Development. ,vol. 59, pp. 245- 251 ,(2013) , 10.1262/JRD.2012-137
Bo Liu, Shaoying Lu, Shuai Zheng, Zonglai Jiang, Yingxiao Wang, Two distinct phases of calcium signalling under flow. Cardiovascular Research. ,vol. 91, pp. 124- 133 ,(2011) , 10.1093/CVR/CVR033
Hadas Bar-Joseph, Irit Ben-Aharon, Shulamith Rizel, Salomon M. Stemmer, Moran Tzabari, Ruth Shalgi, Doxorubicin-induced apoptosis in germinal vesicle (GV) oocytes. Reproductive Toxicology. ,vol. 30, pp. 566- 572 ,(2010) , 10.1016/J.REPROTOX.2010.07.003
T. Pozzan, P. Magalhães, R. Rizzuto, The comeback of mitochondria to calcium signalling Cell Calcium. ,vol. 28, pp. 279- 283 ,(2000) , 10.1054/CECA.2000.0166
Qin Wang, Dhaarmini Rajshankar, Donald R. Branch, Katherine A. Siminovitch, Maria Teresa Herrera Abreu, Gregory P. Downey, Christopher A. McCulloch, Protein-tyrosine Phosphatase-α and Src Functionally Link Focal Adhesions to the Endoplasmic Reticulum to Mediate Interleukin-1-induced Ca2+ Signaling Journal of Biological Chemistry. ,vol. 284, pp. 20763- 20772 ,(2009) , 10.1074/JBC.M808828200
JG Van Oosterwijk, MAJH Van Ruler, IH Briaire-de Bruijn, B Herpers, H Gelderblom, B Van De Water, JVMG Bovée, None, Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells British Journal of Cancer. ,vol. 109, pp. 1214- 1222 ,(2013) , 10.1038/BJC.2013.451
D A Dodd, J B Atkinson, R D Olson, S Buck, B J Cusack, S Fleischer, R J Boucek, Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model. Journal of Clinical Investigation. ,vol. 91, pp. 1697- 1705 ,(1993) , 10.1172/JCI116379
Pengfei Lin, YanZhou Yang, Xiao Li, Fenglei Chen, ChenChen Cui, Linyong Hu, Qian Li, Wei Liu, YaPing Jin, Endoplasmic reticulum stress is involved in granulosa cell apoptosis during follicular atresia in goat ovaries Molecular Reproduction and Development. ,vol. 79, pp. 423- 432 ,(2012) , 10.1002/MRD.22045
A.A Tokmakov, K.-I Sato, T Iwasaki, Y Fukami, Src kinase induces calcium release in Xenopus egg extracts via PLCγ and IP3-dependent mechanism Cell Calcium. ,vol. 32, pp. 11- 20 ,(2002) , 10.1016/S0143-4160(02)00078-7