microRNA-665 promotes the proliferation and matrix degradation of nucleus pulposus through targeting GDF5 in intervertebral disc degeneration.

作者: Hongyu Tan , Liang Zhao , Ruipeng Song , Yilin Liu , Limin Wang

DOI: 10.1002/JCB.26888

关键词:

摘要: … Furthermore, miR-665 overexpression decreased aggrecan and Col II expression and … Elevated expression of miR-665 enhanced NP cell proliferation and decreased aggrecan and Col …

参考文章(42)
Ying-Fang Song, Xiao-Peng Lan, Qing-An Lin, Guo-Xiang Lai, Jing-Fang Hong, De-Ling Liu, miR-630 targets LMO3 to regulate cell growth and metastasis in lung cancer. American Journal of Translational Research. ,vol. 7, pp. 1271- 1279 ,(2015)
Zheng Li, Jianxiong Shen, William Ka Kei Wu, Xin Yu, Jinqian Liang, Guixing Qiu, Jiaming Liu, None, The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells Journal of Orthopaedic Research. ,vol. 31, pp. 847- 857 ,(2013) , 10.1002/JOR.22308
Siyuan Li, Victor C. Duance, Emma J. Blain, Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc Journal of Anatomy. ,vol. 213, pp. 725- 732 ,(2008) , 10.1111/J.1469-7580.2008.00998.X
Ben M. Minogue, Stephen M. Richardson, Leo A. H. Zeef, Anthony J. Freemont, Judith A. Hoyland, Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation Arthritis & Rheumatism. ,vol. 62, pp. 3695- 3705 ,(2010) , 10.1002/ART.27710
Carla Loreto, Giuseppe Musumeci, Alessandro Castorina, Corrado Loreto, Giuseppa Martinez, Degenerative disc disease of herniated intervertebral discs is associated with extracellular matrix remodeling, vimentin-positive cells and cell death Annals of Anatomy - Anatomischer Anzeiger. ,vol. 193, pp. 156- 162 ,(2011) , 10.1016/J.AANAT.2010.12.001
Hongzhe Liu, Xiangwang Huang, Xiangyang Liu, Sheng Xiao, Yi Zhang, Tiecheng Xiang, Xiongjie Shen, Guoping Wang, Bin Sheng, miR-21 Promotes Human Nucleus Pulposus Cell Proliferation through PTEN/AKT Signaling International Journal of Molecular Sciences. ,vol. 15, pp. 4007- 4018 ,(2014) , 10.3390/IJMS15034007
Christine L Le Maitre, Stephen MA Richardson, Pauline Baird, Anthony J Freemont, Judith A Hoyland, Expression of receptors for putative anabolic growth factors in human intervertebral disc : implications for repair and regeneration of the disc The Journal of Pathology. ,vol. 207, pp. 445- 452 ,(2005) , 10.1002/PATH.1862