Dual color fluorescence in situ hybridization to investigate aneuploidy in sperm from 33 normal males and a man with a t(2;4;8)(q23;q27;p21) *

摘要: Objective To establish the relative frequency of aneuploidy in sperm from normal and abnormal subjects using dual color fluorescence situ hybridization probes for six different chromosomes. Design Semen 33 males a patient with translocation was studied chromosomes 4, 7, 8, 12, 18, X Y. The each chromosome is compared one another who had t(2;4;8)(q23;q27;p21). Setting Specimens were obtained patients at Mayo Clinic, Rochester, Minnesota. Results percentage disomy or nullisomy ranged 0.2% to 0.6% studied. No statistically significant differences observed between these t(2;4;8) 3.3% 4.8% 4 respectively. Conclusion Fluorescence useful range nullisomic disomic study clinically abnormality. In males, no difference meiotic nondisjunction among