HIV-2 Surveillance with Next-Generation Sequencing Reveals Mutations in a Cytotoxic Lymphocyte-Restricted Epitope Involved in Long-Term Nonprogression

摘要: Abstract HIV-2 exhibits a natural history of infection distinct from HIV-1. Primarily found in West Africa and only 10%–20% HIV infections this region, patients with typically exhibit slower progression to AIDS, lower viral loads, decreased rates transmission. Here, we used next-generation sequencing determine the sequence phylogenetic classification nine genomes. We identified patient series mutations an invariant cytotoxic lymphocyte (CTL)-restricted gag epitope required for retroviral structure replication implicated long-term nonprogression AIDS. The presence wild-type argues these are involved immune escape, whereas its reversion seen sooty mangabey reservoir suggests alternate means controlling infection. Surveillance molecular characterization circulating strains essential continued development monitoring tools may provide greater insight into reduc...