Venous thrombosis in older people: prevalence of the factor V gene mutation Q506.

摘要: OBJECTIVES: Old age is usually considered to be a risk factor for venous thromboembolism, in conjunction with other factors such as heart failure, major surgery, cancer, long-term immobilization, and antiphospholipid antibodies. Genetic factors, especially inherited deficiencies coagulation inhibitors, also play role the pathogenesis of thrombosis, but these are diagnosed thrombophilic patients before 50. The V Q506 mutation, responsible activated protein C resistance, was recently linked thromboembolic disease. We therefore investigated prevalence biological older hospital thromboembolism. DESIGN: A 2-year study period. SETTING: Ivry sur Seine (Paris), France. PARTICIPANTS: Seventy-nine geriatric (60 women 19 men, mean 83 ± 6.8 years, range 70–102 years) who had at least one proven episode thromboembolism were enrolled over period. MEASUREMENTS: Lupus anticoagulant antithrombin (AT), (PC), S (PS) levels determined plasma. mutation detected on genomic DNA. RESULTS: two women, whom high level anticardiolipin IgG, leading diagnosis an syndrome. No hereditary deficiency AT, PC, or PS found, patient acquired AT deficiency. Interestingly, nine 79 (11.4%, six three men) heterozygous although none homozygous. only thrombosis identified prolonged immobilization four cases. Four recurrent been immobilized long periods. CONCLUSIONS: This confirms that lupus anticoagulant, rarely involved subjects. In contrast, frequently associated (11.4% our patients) should, therefore, important people.