Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma
作者： Liang Zhao
关键词:
摘要: AIM: To investigate the expression of leptin and receptor (ob-R) in intestinal-type gastric cancer precancerous lesions, to explore possible mechanism role system developing adenocarcinoma. METHODS: Immunohistochemistry was performed examine archival samples adenocarcinoma preneoplastic including intestinal metaplasia mild severe epithelial dysplasia. Positive staining identified percentage positive graded. RESULTS: Dual were detected 80% (16/20) metaplasia, 86.3% (25/30) dysplasia, 86.7% (26/30) moderate 93.3% (28/30) 91.3% (55/60) 30.0% (9/30) diffuse-type carcinoma. The dual significantly higher than that (χ2 = 37.022, P<0.01). CONCLUSION: Our results indicate presence an autocrine loop development adenocarcinoma.
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