摘要: An ever-expanding list of protein kinases is now known to serve diverse physiological roles in cellular systems (Table I). By phosphorylating serine, threonine or tyrosine residues target proteins, these enzymes transduce metabolic hormonal signals with profound consequences (Krebs & Beavo, 1979; Flockhart Corbin, 1982; Nishizuka, 1984; Stull et al., 1985). Serine- threonine-specific were first found exercise control processes. Tyrosine-specific are both as domains trans-membrane growth factor receptors and encoded by viral oncogenes (Sefton Hunter, Thus, some integral membrane proteins that directly involved the transduction extracellular for intracellular purposes. Others act amplifiers signals, regulators structural enzymatic components cells, unregulated products certain oncogenic lesions.
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sci-hub.st 参考文章(20)
Margaret O. Dayhoff, Winona C. Barker, Lois T. Hunt, [47] Establishing homologies in protein sequences Enzyme Structure Part I. ,vol. 91, pp. 524- 545 ,(1983) , 10.1016/S0076-6879(83)91049-2
Jeff KURET, James R. WOODGETT, Philip COHEN, Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Identification of the sites phosphorylated by casein kinase-I. FEBS Journal. ,vol. 151, pp. 39- 48 ,(1985) , 10.1111/J.1432-1033.1985.TB09066.X
T. M. Lincoln, J. D. Corbin, Adenosine 3':5'-cyclic monophosphate- and guanosine 3':5'-cyclic monophosphate-dependent protein kinases: possible homologous proteins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 3239- 3243 ,(1977) , 10.1073/PNAS.74.8.3239
Yasutomi Nishizuka, The role of protein kinase C in cell surface signal transduction and tumour promotion Nature. ,vol. 308, pp. 693- 698 ,(1984) , 10.1038/308693A0
R. Doolittle, Similar Amino Acid Sequences: Chance or Common Ancestry? Science. ,vol. 214, pp. 149- 159 ,(1981) , 10.1126/SCIENCE.7280687
Erwin M. Reimann, Koiti Titani, Lowell H. Ericsson, Roger D. Wade, Edmond H. Fischer, Kenneth A. Walsh, Homology of the gamma subunit of phosphorylase b kinase with cAMP-dependent protein kinase. Biochemistry. ,vol. 23, pp. 4185- 4192 ,(1984) , 10.1021/BI00313A027
P. Parker, L Coussens, N Totty, L Rhee, S Young, E Chen, S Stabel, M. Waterfield, A Ullrich, The complete primary structure of protein kinase C--the major phorbol ester receptor. Science. ,vol. 233, pp. 853- 859 ,(1986) , 10.1126/SCIENCE.3755547
E G Krebs, J A Beavo, Phosphorylation-dephosphorylation of enzymes. Annual Review of Biochemistry. ,vol. 48, pp. 923- 959 ,(1979) , 10.1146/ANNUREV.BI.48.070179.004423
Koji Takio, Donald K. Blumenthal, Arthur M. Edelman, Kenneth A. Walsh, Edwin G. Krebs, Koiti Titani, Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase Biochemistry. ,vol. 24, pp. 6028- 6037 ,(1985) , 10.1021/BI00343A002
J. Downward, Y. Yarden, E. Mayes, G. Scrace, N. Totty, P. Stockwell, A. Ullrich, J. Schlessinger, M. D. Waterfield, Close similarity of epidermal growth factor receptor and v- erb-B oncogene protein sequences Nature. ,vol. 307, pp. 521- 527 ,(1984) , 10.1038/307521A0