A compartmental analysis of circulatory lymphocytes in the spleen.

摘要: A tentative model describing the passage of circulatory lymphocytes through spleen is formulated in accord with known anatomical features. In order to preserve isomorphism between and splenic system, compartmental form its design allows alternative routes modes lymphocyte transit be considered. The simultaneous differential equations arising from are solved using an analogue computer which also provides means whereby performance may compared suitable dynamic data drawn literature. This not only selection a particular configuration preference alternatives, but numerical determination certain unknown parameters. case rat spleen, best agreement experimental obtained when 10 25% total flux passes marginal zone where average dwell time about 50 min. white pulp receives amounting 10% sequestered for period 4-6 hr before release venous circulation. red 90% majority find less than 5 remaining lymphocytes, input, delayed by 2-3