Solubilisation capacity of Brij surfactants.
作者： Maria E.N.P. Ribeiro , Carolina L. de Moura , Mariano G.S. Vieira , Nilce V. Gramosa , Chiraphon Chaibundit
DOI: 10.1016/J.IJPHARM.2012.07.032
关键词:
摘要: The aim of this study was to investigate the potential selected Brij non-ionic surfactants for enhancing solubility poorly water-soluble drugs. Griseofulvin as a model drug candidate enabling comparisons be made with solubilisation capacities other poly(ethylene oxide)-based copolymers. UV/Vis and (1)H NMR spectroscopies were used quantify enhancement griseofulvin in 1 wt% aqueous micellar solutions 78 (C(18)H(37)E(20)), 98 (C(18)H(35)E(20)) 700 (C(18)H(37)E(100)) (where E represents OCH(2)CH(2) unit oxide) chain) at 25, 37 40 °C. Solubilisation (S(cp) expressed mg per g Brij) similar (range 6-11 g(-1)) but lower (3-4 would expected surfactant higher ethylene oxide content. loading capacity micelles than many di- triblock copolymers hydrophilic E-blocks specifically designed solubility.
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