Microbleeds Versus Macrobleeds Evidence for Distinct Entities

摘要: Background and Purpose— Small, asymptomatic microbleeds commonly accompany larger symptomatic macrobleeds. It is unclear whether macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies. Methods— We performed 2 complementary retrospective analyses. In radiographic analysis, we measured plotted the volumes of all hemorrhagic lesions detected by gradient-echo MRI among 46 consecutive patients primary lobar intracerebral hemorrhage diagnosed as probable or possible cerebral amyloid angiopathy. second neuropathologic blinded qualitative quantitative examinations amyloid-positive vessel segments in 6 autopsied subjects whose scans demonstrated particularly high microbleed counts (>50 on MRI, n=3) low (<3 microbleeds, n=3). Results— Plotted logarithmic scale, 163 identified from the...