Neuroendocrine Mechanisms Underlying the Control of Gonadotropin Secretion by Steroids

摘要: There is considerable evidence that although estradiol may trigger the preovulatory surge of gonadotropins, progesterone required for its full magnitude and duration glucocorticoids bring about selective follicle-stimulating hormone release. The luteinizing hormone-releasing (LHRH) neuron does not have steroid receptors regulated by excitatory amino acid neurotransmission. Steroids do appear to modulate directly but increase release glutamate in preoptic area. This be due suppression steroids enzyme glutamatic decarboxylase67 converts into GABA. NMDA colocalize with nitric oxide synthase-containing neurons surround LHRH area intersect fibers median eminence. Other potential novel pathways are currently being explored include carbon monoxide generated action heme oxygenase-2 on molecules bradykinin acting via B2 receptors.