Gene deregulation in gastric cancer
作者： Michael Stock , Florian Otto
DOI: 10.1016/J.GENE.2005.06.026
关键词:
摘要: Despite its decreasing frequency in the Western world during recent decades, gastric cancer is still one of leading causes cancer-related deaths worldwide. Due to oligosymptomatic course early cancer, most cases are diagnosed advanced stages disease. The curative potential current standard treatment continues be unsatisfactory, despite multimodal approaches involving surgery, chemotherapy and radiotherapy. Novel therapeutics including small molecules monoclonal antibodies being developed have been partially introduced into clinical use connection with neoplastic diseases such as chronic myeloid leukemia, non-Hodgkin's lymphoma colorectal cancer. Thorough understanding changes gene expression occurring carcinogenesis may help develop targeted therapies improve this molecular biology techniques generated a wealth data on up- down-regulation, activation inhibition specific pathways Here, we provide an overview different aspects aberrant patterns
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Kiyomi Taniyama, Hiromichi Sumiyoshi, Eiichi Tahara, Wataru Yasui, Shinji Nagae, Jotaro Hata, Tomonori Hayashi, Shunji Sakamoto, Human epidermal growth factor in gastric carcinoma as a biologic marker of high malignancy Japanese Journal of Cancer Research. ,vol. 77, pp. 145- 152 ,(1986) , 10.20772/CANCERSCI1985.77.2_145
R. Fiocca, L. Villani, P. Tenti, E. Solcia, M. Cornaggia, B. Frigerio, C. Capella, Characterization of four main cell types in gastric cancer: foveolar, mucopeptic, intestinal columnar and goblet cells. An histopathologic, histochemical and ultrastructural study of "early" and "advanced" tumours. Pathology Research and Practice. ,vol. 182, pp. 308- 325 ,(1987) , 10.1016/S0344-0338(87)80066-3
Thun Mj, Calle Ee, Namboodiri Mm, Flanders Wd, Heath Cw, Aspirin Use and Risk of Fatal Cancer Cancer Research. ,vol. 53, pp. 1322- 1327 ,(1993)
Masashi Fukayama, Ja-Mun Chong, Hirokazu Taniguchi, Shuichi Tsutsumi, Hiroyuki Aburatani, Naoko Machida, Yoshitaka Hippo, Tatsuhiko Kodama, Global Gene Expression Analysis of Gastric Cancer by Oligonucleotide Microarrays Cancer Research. ,vol. 62, pp. 233- 240 ,(2002)
Henry T. Lynch, Thomas C. Smyrk, Patrice Watson, Stephen J. Lanspa, Jane F. Lynch, Patrick M. Lynch, R.Jennifer Cavalieri, C.Richard Boland, Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review Gastroenterology. ,vol. 104, pp. 1535- 1549 ,(1993) , 10.1016/0016-5085(93)90368-M
Setsuo Hirohashi, Yutaka Shimoyama, Expression of E- and P-cadherin in gastric carcinomas. Cancer Research. ,vol. 51, pp. 2185- 2192 ,(1991)
C. Rahj Robinson, Stanley R. Hamilton, Steven M. Powell, Jeffrey C. Harper, Oscar W. Cummings, Inactivation of Smad4 in Gastric Carcinomas Cancer Research. ,vol. 57, pp. 4221- 4224 ,(1997)
Timothy Bestor, Andrew Laudano, Robert Mattaliano, Vernon Ingram, Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells: The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases☆ Journal of Molecular Biology. ,vol. 203, pp. 971- 983 ,(1988) , 10.1016/0022-2836(88)90122-2
Andrew M Lowy, Amod Sarnaik, On Ja Kim, Joanna Groden, Jiang Wang, Cecilia Fenoglio-Preiser, Jack MacDonald, Wilson M Clements, beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Research. ,vol. 62, pp. 3503- 3506 ,(2002)
Hidenobu Watanabe, Munetomo Enjoji, Tsuneyoshi Yao, Keiichi Ohsato, Gastric lesions in familial adenomatosis coli: their incidence and histologic analysis. Human Pathology. ,vol. 9, pp. 269- 283 ,(1978) , 10.1016/S0046-8177(78)80085-9