Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model

摘要: Breast cancer has been recognized as the leading cause of death in women worldwide. Research shown importance complementary and alternative therapies cancer. In this study, we investigated antitumoural therapeutic effects Malaysian Tualang honey (TH) Australian/New Zealand Manuka (MH) against breast rats. Thirty syngeneic virgin female Sprague-Dawley (SD) rats were induced by carcinogen 1-methyl-1-nitrosourea (MNU) 80 mg/kg. The treatment started when first palpable tumour reached 10–12 mm size dividing into following groups: Group 0 (negative control); 1 (positive Groups 2 3 which received 1.0 g/kg body weight/day TH MH, respectively, for 120 days. data demonstrate that masses MH treated groups showed a lower median size, weight, multiplicity compared with nontreated positive control ( ). Treatment also dramatic slower growth rate (up to 70.82%) (0%) effect was mediated through modulation growth, grading, estrogenic activity, haematological parameters. Our findings systemic administration increases susceptibility expression proapoptotic proteins (Apaf-1, Caspase-9, IFN-γ, IFNGR1, p53) decreases antiapoptotic (TNF-α, COX-2, Bcl-xL 1) its mechanism action. This highlights potential novel role alleviating