Thyrotoxicosis as a Disease of Mitochondria

摘要: THE physiologic manifestations of the cellular action thyroid hormones are documented extensively. The high basal metabolic rate hyperthyroid mammal1 is accompanied by an increased oxidation in most tissues2; this suggested, as early 1927, that thyroxine a necessary component, or coenzyme, oxidative enzymes.3 A review investigations up to 1951 based upon such hypothesis, however, does not define enzyme system enzymes requiring for action.4 Biochemical since time demonstrate produce functional changes phosphorylation and structural mitochondria. . . .