Loss of DCC Expression and Glioma Progression

摘要: The deleted in colorectal cancer (DCC) gene, a candidate tumor suppressor gene on chromosome 18q21, encodes neural cell adhesion molecule family protein that is most highly expressed the nervous system. To address hypothesis DCC may play role glioma development and/or progression, we examined expression by immunohistochemistry 57 resected human astrocytic tumors. Overall, low-grade astrocytomas were predominantly positive (15 of 16, or 94%), whereas high-grade tumors significantly less often (27 41, 66%; P = 0.03). We able to directly assess relationship between and progression 15 patients who initially presented with astrocytoma subsequently recurred glioblastoma. Within this panel paired lesions from same patient, 14 (93%) protein, only 7 (47%) corresponding glioblastomas positive. also observed secondary resulting malignant more negative (8 15, 53%) compared primary de novo (6 26, 23%; 0.05). These findings implicate inactivation demonstrate preferentially, but not exclusively, lost genetic pathway glioblastoma multiforme.