Smart Macroporous IPN Hydrogels Responsive to pH, Temperature, and Ionic Strength: Synthesis, Characterization, and Evaluation of Controlled Release of Drugs.
作者： Ecaterina Stela Dragan , Ana Irina Cocarta
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摘要: Fast responsive macroporous interpenetrating polymer network (IPN) hydrogels were fabricated in this work by a sequential strategy, as follows: the first network, consisting of poly(N,N-dimethylaminoethyl methacrylate) (PDMAEM) cross-linked with N,N′-methylenebisacrylamide (BAAm), was prepared at −18 °C, second poly(acrylamide) (PAAm) BAAm, being also generated cryogelation technique. Both single cryogels (SNC) and IPN characterized Fourier transform infrared spectroscopy, scanning electron microscopy, water uptake. The presence weak polycation PDMAEM endows SNCs IPNs sensitivity numerous external stimuli such pH, temperature, ionic strength, electric field, among which three investigated work. It found that initial concentration monomers both networks key factor tailoring properties swelling kinetics, equilibrium c...
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