Antileukemic effect of Kalpaamruthaa, a modified Siddha preparation, in BCR–ABL + cell line induced chronic myeloid leukemic mouse model

摘要: Kalpaamruthaa is a modified Siddha (herbal) drug prepared in our laboratory. It has been proven to have therapeutic effect against arthritis, mammary cancer, and liver cancer. To evaluate the antileukemic of drug, (KA), chronic myeloid leukemia-induced mice, leukemia was induced BALB/c mice by tail vein injection BCR–ABL +12B1 murine cell line. Leukemia-induced animals were treated with KA at dosage 200 mg/kg b.wt. dissolved 0.5 ml olive oil for 14 days, daily gastric intubation. Imatinib mesylate used as reference drug. The significantly decreased levels marker enzymes lipid peroxides increased antioxidant enzymes. bone marrow histopathological abnormalities also found be normalized after treatment KA. No significant adverse observed sole drug-treated group rats. present study suggests that KA, means its free radical quenching effect, definite anti cancer leukemic mice.