NMDA and D1 receptors mediate induction of c-fos and junB genes in striatum following morphine administration: implications for studies of memory.
作者： Frank R. Sharp , Jialing Liu , Jeremy Nickolenko , Bruno Bontempi
DOI: 10.1016/0166-4328(94)00146-7
关键词:
摘要: The c-fos and junB immediate early genes (IEGs) were induced in neurons of the medial ventral striatum following administration morphine. striatal induction mRNA Fos protein was blocked by naloxone, D1 dopamine (DA) receptor antagonists, SCH23390 SCH39166, N-methyl-D-aspartate (NMDA) glutamate antagonist, MK801. MK801 did not block morphine septum. Since pattern nucleus accumbens similar to that observed with cocaine amphetamine [2,18,45,51], these data support current concepts limbic are among brain regions mediate drug abuse [9,10,23,27,49]. If it is true receptors activate CRE (cyclase response element) NMDA SRE (serum promoter [1], then this suggests serial activation mu opiate, on different required induce Moreover, concurrent for neurons. simultaneous should lead long-term changes gene expression might also be involved circuits could form basis 'memories' relating prior exposure addictive drugs.
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sci-hub.se 参考文章(51)
LS Lerea, LS Butler, JO McNamara, NMDA and non-NMDA receptor-mediated increase of c-fos mRNA in dentate gyrus neurons involves calcium influx via different routes. The Journal of Neuroscience. ,vol. 12, pp. 2973- 2981 ,(1992) , 10.1523/JNEUROSCI.12-08-02973.1992
EJ Nestler, Molecular mechanisms of drug addiction. The Journal of Neuroscience. ,vol. 12, pp. 2439- 2450 ,(1992) , 10.1523/JNEUROSCI.12-07-02439.1992
S. Berretta, H. A. Robertson, A. M. Graybiel, Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum. Journal of Neurophysiology. ,vol. 68, pp. 767- 777 ,(1992) , 10.1152/JN.1992.68.3.767
CR Gerfen, JF McGinty, WS Young, Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis The Journal of Neuroscience. ,vol. 11, pp. 1016- 1031 ,(1991) , 10.1523/JNEUROSCI.11-04-01016.1991
V L Coffin, R E Chipkin, A Barnett, J G Berger, L C Iorio, R D McQuade, Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity. Journal of Pharmacology and Experimental Therapeutics. ,vol. 247, pp. 1093- 1102 ,(1988)
FR Sharp, SM Sagar, K Hicks, D Lowenstein, K Hisanaga, c-fos mRNA, Fos, and Fos-related antigen induction by hypertonic saline and stress The Journal of Neuroscience. ,vol. 11, pp. 2321- 2331 ,(1991) , 10.1523/JNEUROSCI.11-08-02321.1991
H.A. Robertson, M.R. Peterson, K. Murphy, G.S. Robertson, D1-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behaviour. Brain Research. ,vol. 503, pp. 346- 349 ,(1989) , 10.1016/0006-8993(89)91689-2
Roger P. Dilts, Todd E. Helton, Jaqueline F. McGinty, Selective induction of Fos and FRA immunoreactivity within the mesolimbic and mesostriatal dopamine terminal fields. Synapse. ,vol. 13, pp. 251- 263 ,(1993) , 10.1002/SYN.890130308
H Bading, D. Ginty, M. Greenberg, Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways Science. ,vol. 260, pp. 181- 186 ,(1993) , 10.1126/SCIENCE.8097060
Kinya Hisanaga, Stephen M. Sagar, Frank R. Sharp, N-Methyl-D-Aspartate Antagonists Block Fos-Like Protein Expression Induced via Multiple Signaling Pathways in Cultured Cortical Neurons Journal of Neurochemistry. ,vol. 58, pp. 1836- 1844 ,(1992) , 10.1111/J.1471-4159.1992.TB10060.X