C-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma
作者： Glenna C. Burmer , Douglas S. Levine , Bruce G. Kulander , Rodger C. Haggitt , Cyrus E. Rubin
DOI: 10.1016/0016-5085(90)91024-Z
关键词:
摘要: Mutations in the first exon of c-Ki-ras protooncogene were analyzed carcinomas and dysplasias from patients with sporadic colon cancer chronic ulcerative colitis by a combination histological enrichment, cell sorting, polymerase catalyzed chain reaction, direct sequencing. In contrast to carcinomas, where 52% (11 21) contained mutations codon 12, only 1 28 samples associated carcinoma or dysplasia mutation, despite presence aneuploid populations. These results suggest that different genetic pathway for tumor progression may exist between arising colitis.
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