A novel test of conditioned inhibition correlates with personality measures of schizotypy and reward sensitivity.

摘要: Conditioned inhibition is demonstrated when the meaning of one signal (conditioned stimulus, CS) qualified by another inhibitor, CI). Whilst CS presented alone reliably predicts outcome (unconditioned US), in conjunction with CI otherwise expected US will not occur. has long been established animal research but there have difficulties establishing reliable procedures suitable for use human research. Such are necessary to investigate disorders which cognitive inhibitory mechanisms known be deficient, e.g., schizophrenia. In healthy participants, individual differences tendency show conditioned should related personality measures inhibition. present study, this was measured using an automated test procedure, visual stimuli predict occurrence or non-occurrence a US, and BIS/BAS schizotypy scales. across two alternative variants, specified differently, confirmed summation tests. The level shown positively associated BAS Reward Responsiveness did correlate significantly any other Conversely, negatively schizotypy. We suggest that novel task now applied range some basis dysfunctional processes, such as