High Serum SHBG Predicts Incident Vertebral Fractures in Elderly Men.

摘要: Previous prospective cohort studies have shown that serum levels of sex steroids and hormone‐binding globulin (SHBG) associate with nonvertebral fracture risk in men. The predictive value hormones SHBG for vertebral specifically is, however, less studied. Elderly men (aged ≥65 years) from Sweden Hong Kong participating the Osteoporotic Fractures Men (MrOS) study had baseline estradiol testosterone analyzed by gas chromatography–mass spectrometry (GC‐MS) immunoradiometric assay (IRMA). Incident clinical fractures (n = 242 cases) were evaluated 4324 during an average follow‐up 9.1 years. In a subsample these (n = 2256), spine X‐rays obtained at after 4.3 years to identify incident radiographic (n = 157 cases). likelihood was estimated Cox proportional hazards models logistic regression models, respectively. Neither (hazard ratio [HR] per SD increase = 0.93, 95% confidence interval [CI] 0.80–1.08) nor (1.05, 0.91–1.21) predicted age‐adjusted combined data set. High SHBG, associated increased (1.24, 1.12–1.37). This association remained significant further adjustment FRAX or without bone mineral density (BMD). also (combined set; odds [OR] increase = 1.23, CI 1.05–1.44). BMD. conclusion, high predicts elderly adds moderate information beyond BMD prediction. © 2015 Authors. Journal Bone Mineral Research published Wiley Periodicals, Inc. on behalf American Society Research.