作者: Philip E Silkoff , Richard J Martin
DOI: 10.1016/S1081-1206(10)63134-1
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摘要: Learning objectives This article will focus on the pathophysiologic changes underlying nocturnal worsening of asthma and therapeutic approach to this disorder. Data sources Selected articles appearing since 1985 dealing specifically with pathologic features therapy asthma. Results Nocturnal is associated significant decline in pulmonary function increase airway inflammation at night. The administration medications must be designed achieve maximal effect during night Conclusions further elucidation reasons should lead more specific interventions