Trpv1+ sensory neurons control of beta-cell stress and islet inflammation in diabetes
作者： Michael Salter , Lan Tang , Yin Chan , Rozita Razavi-Drakhshi , Hans-Michael Dosch
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摘要: A process is disclosed for controlling inflammatory tissue access through release of neuropeptides, such as substance P (sP), to insulin-responsive sensory neurons, whereby simultaneous control insulin sensitivity/resistance manifested. In models Type 1 and 2 diabetes, afferents, in particular TRPV1, have fundamental roles insulin/glucose homeostasis, islet physiology autoimmune inflammation. By manipulation the TRPV1 neuro-β-cell circuit or enhancement pancreatic sP levels, normalization resistance, clearance inflammation prevention both diabetes realized.
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