Using the Coronary Artery Calcium Score to Predict Coronary Heart Disease Events

摘要: Background Primary prevention of coronary heart disease is most appropriate for patients at relatively high risk. Measurement artery calcium has been proposed as a way to improve risk assessment, but it unknown whether adds predictive information standard factor assessment. Methods We systematically searched electronic databases relevant articles published between January 1, 1980, and March 19, 2003, hand bibliographies. included studies that reported measuring the score by electron beam computed tomography in asymptomatic subjects subsequent follow-up those events presented score-specific relative risks, adjusted established factors. Two abstractors verified inclusion criteria abstracted data from each study. estimated risks associated with 3 categories scores (1-100, 101-400, >400), compared 0, used random-effects model meta-analysis. Results Meta-analysis 4 meeting yielded summary 2.1 (95% confidence interval, 1.6-2.9) 1 100. Relative estimates higher were higher, ranging 3.0 17.0 varied significantly among studies. Subgroup analyses suggested differences outcome adjudication (blinded or not), measurement other factors (direct patient history), tomographic slice thickness (3 6 mm), and/or proportion female study may account this heterogeneity. Conclusion The an independent predictor events.