Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1

作者: Takeshi Gohongi , Dai Fukumura , Yves Boucher , Chae-Ok Yun , Gerald A. Soff

DOI: 10.1038/13524

关键词:

摘要: Angiogenesis inhibitors produced by a primary tumor can create systemic anti-angiogenic environment and maintain metastatic cells in state of dormancy. We show here that the gallbladder microenvironment modulates production transforming growth factor (TGF)-beta1, multifunctional cytokine functions as an endogenous anti-tumor cranial window preparation. found wide variety human tumors express TGF-beta1 irrespective histologic type. implanted gel impregnated with basic fibroblast or Mz-ChA-2 windows mice without subcutaneous to study angiogenesis at secondary site. Angiogenesis, leukocyte-endothelial interaction vessels were substantially inhibited tumors. The concentration plasma was 300% higher than In contrast, there no difference levels other anti- pro-angiogenic factors. Treatment neutralizing antibody against reversed both suppression inhibition leukocyte rolling induced also cell proliferation. Our results indicate anti-angiogenesis/proliferation factors is regulated tumor-host interactions.

参考文章(25)
J Wang, L I Gold, E Friedman, A Picon, A Cohen, A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1. Cancer Epidemiology, Biomarkers & Prevention. ,vol. 7, pp. 497- 504 ,(1998)
I. J. Fidler, Modulation of the Organ Microenvironment for Treatment of Cancer Metastasis Journal of the National Cancer Institute. ,vol. 87, pp. 1588- 1592 ,(1995) , 10.1093/JNCI/87.21.1588
Prionas Sd, Fajardo Lf, Kowalski J, Allison Ac, Kwan Hh, Transforming growth factor beta1 induces angiogenesis in vivo with a threshold pattern. Laboratory Investigation. ,vol. 74, pp. 600- 608 ,(1996)
Thomas Doetschman, Gregory P. Boivin, Peter S. Gartside, Sandra J. Engle, Ilona Ormsby, James B. Hoying, Transforming Growth Factor β1 Suppresses Nonmetastatic Colon Cancer at an Early Stage of Tumorigenesis Cancer Research. ,vol. 59, pp. 3379- 3386 ,(1999)
Nina Safabakhsh, Rakesh K. Jain, Marc Dellian, Axel Sckell, Primary Tumor Size-dependent Inhibition of Angiogenesis at a Secondary Site: An Intravital Microscopic Study in Mice Cancer Research. ,vol. 58, pp. 5866- 5869 ,(1998)
Y Khew-Goodall, J R Gamble, M A Vadas, Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells. Journal of Immunology. ,vol. 150, pp. 4494- 4503 ,(1993)
Peter Carmeliet, Yuval Dor, Jean-Marc Herbert, Dai Fukumura, Koen Brusselmans, Mieke Dewerchin, Michal Neeman, Françoise Bono, Rinat Abramovitch, Patrick Maxwell, Cameron J. Koch, Peter Ratcliffe, Lieve Moons, Rakesh K. Jain, Désiré Collen, Eli Keshet, Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. ,vol. 394, pp. 485- 490 ,(1998) , 10.1038/28867
Rosemary A. Walker, Sheila J. Dearing, Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast European Journal of Cancer. ,vol. 28, pp. 641- 644 ,(1992) , 10.1016/S0959-8049(05)80116-9
D. Theodorescu, M. Caltabiano, R. Greig, D. Rieman, R. S. Kerbel, Reduction of TGF-beta activity abrogates growth promoting tumor cell-cell interactions in vivo. Journal of Cellular Physiology. ,vol. 148, pp. 380- 390 ,(1991) , 10.1002/JCP.1041480308