作者: Takeshi Gohongi , Dai Fukumura , Yves Boucher , Chae-Ok Yun , Gerald A. Soff
DOI: 10.1038/13524
关键词:
摘要: Angiogenesis inhibitors produced by a primary tumor can create systemic anti-angiogenic environment and maintain metastatic cells in state of dormancy. We show here that the gallbladder microenvironment modulates production transforming growth factor (TGF)-beta1, multifunctional cytokine functions as an endogenous anti-tumor cranial window preparation. found wide variety human tumors express TGF-beta1 irrespective histologic type. implanted gel impregnated with basic fibroblast or Mz-ChA-2 windows mice without subcutaneous to study angiogenesis at secondary site. Angiogenesis, leukocyte-endothelial interaction vessels were substantially inhibited tumors. The concentration plasma was 300% higher than In contrast, there no difference levels other anti- pro-angiogenic factors. Treatment neutralizing antibody against reversed both suppression inhibition leukocyte rolling induced also cell proliferation. Our results indicate anti-angiogenesis/proliferation factors is regulated tumor-host interactions.