Evaluation of Risk Factors for Nasopharyngeal Carcinoma in High-Risk Nasopharyngeal Carcinoma Families in Taiwan

摘要: A study of nasopharyngeal carcinoma (NPC) families with two or more affected members was conducted in Taiwan (265 2,444 individuals, 502 and 1,942 unaffected) to determine the association between NPC potential etiologic factors high-risk families. Similar results from a previous case-control Taiwan, Guangdong salted fish consumption during childhood, exposure wood, betel nut were all associated elevated risk using conditional logistic regression, although these associations not as strong possibly due shared environment among family members. Risk cumulative wood before age 10 stronger early age-onset [odds ratio (ORwood), 5.10; 95% confidence interval (95% CI), 1.50-17.34; ORfish, 3.94; CI, 1.47-10.55] three (ORwood, 4.41; 1.58-12.30; 4.27; 1.10-16.47). In contrast, tendency for noted use late (OR, 2.44; 1.16-5.13) CYP2E1 c2 allele less than 2.06; 1.04-3.35). estimates exposures similar when analyses restricted EBV-seropositive subjects. To better adjust degree relationship residual genetic correlations, we also calculated ORs variance components model. The methods indicating that regression unbiased.