Polypeptide nanogels with hydrophobic moieties in the cross-linked ionic cores: synthesis, characterization and implications for anticancer drug delivery

摘要: AbstractPolymer nanogels have gained considerable attention as a potential platform for drug delivery applications. Here we describe the design and synthesis of novel polypeptide-based with hydrophobic moieties in cross-linked ionic cores. Diblock copolymer, poly(ethylene glycol)-b-poly(l-glutamic acid), hydrophobically modified l-phenylalanine methyl ester was used controlled template small size (ca. 70 nm diameter) narrow particle distribution. Steady-state time-resolved fluorescence studies using coumarin C153 indicated existence domains cores nanogels. Stable doxorubicin-loaded were prepared at high capacity (30 w/w%). We show that are enzymatically-degradable leading to accelerated release under simulated lysosomal acidic pH. Furthermore, demonstrate nanogel-based formulation doxorubicin is well tolerated exhibit an improved antitumor activity...