Fibrosis in tissue engineering and regenerative medicine: treat or trigger?

摘要: Fibrosis is a life-threatening pathological condition resulting from dysfunctional tissue repair process. There no efficient treatment and organ transplantation in many cases the only therapeutic option. Here we review engineering regenerative medicine (TERM) approaches to address fibrosis cardiovascular system, kidney, lung liver. These strategies have great potential achieve or replacement of diseased organs by cell- material-based therapies. However, paradoxically, they might also trigger fibrosis. Cases TERM interventions with adverse outcome are included this review. Furthermore, emphasize fact that, although still its infancy, advances field leading biomedically relevant vitro models tremendous for disease recapitulation development human increased predictive power drug responses thereby reducing need animal testing.