Does Campylobacter jejuni infection elicit axonal or demyelinating Guillain–Barré syndrome, or both?

摘要: Guillain–Barre syndrome (GBS) is currently divided into the two major subtypes, acute inflammatory demyelinating polyneuropathy (AIDP) and motor axonal neuropathy (AMAN).1 Whereas gold standard for classification of GBS subtypes neuropathology, in clinical practice most neurologists use electrophysiology to identify nerve demyelination. Using current electrodiagnostic criteria, there a considerable difference geographical distribution subtypes; western countries, >90% cases are diagnosed as having AIDP but East Asia AMAN constitutes 38∼65% cases. The expected be related environmental or genetic factors, particularly preceding infections may determine subtypes. However, both Asian Campylobacter jejuni enteritis common infection GBS.2 This mystery. It now established that certain patients …