Directing bone marrow-derived stromal cell function with mechanics

摘要: Because bone marrow-derived stromal cells (BMSCs) are able to generate many cell types, they envisioned as source of regenerative repair numerous tissues, including bone, cartilage, and ligaments. Success BMSC-based therapies, however, relies on a number methodological improvements, among which better understanding control the BMSC differentiation pathways. Since years, biochemical environment is known govern differentiation, but more recent evidences show that biomechanical also directing functions. Using in vitro systems aim reproduce selected components vivo mechanical environment, it was demonstrated loadings can affect proliferation improve osteogenic, chondrogenic, or myogenic phenotype BMSCs. These effects, seem be modulated by parameters other than mechanics, such substrate nature soluble environment. This paper reviews discusses experimental data showing despite some knowledge limitation, stimulation already constitutes an additional efficient tool drive differentiation.