P0 is an early marker of the Schwann cell lineage in chickens.

摘要: We have generated a monoclonal antibody, termed 1E8, that is specific for myelinating and nonmyelinating Schwann cells in mature chickens. 1E8 first stains at the edge of neural crest; later, located between tube somites sclerotome are immunopositive. Double labeling with HNK-1 indicates these 1E8-positive represent subset crest ventral migratory pathways. later associated dorsal roots extending nerve trunks. In Western blots, reacts proteins comigrating P0. Immunodepletion experiments establish all P0 molecules carry determinant. The developmental distribution P0, as determined by immunoreactivity, differs from reported mammals suggests that, chicken, an early marker cell lineage.