Susceptibility to kainate-induced seizures under dietary zinc deficiency.

摘要: Zinc homeostasis in the brain is altered by dietary zinc deficiency, and its alteration may be associated with etiology manifestation of epileptic seizures. In present study, susceptibility to kainate-induced seizures was enhanced mice fed a zinc-deficient diet for 4 weeks. When Timm's stain performed estimate concentrations synaptic vesicles, attenuated mice. rats 4 weeks, also enhanced. release neurotransmitters hippocampal extracellular fluid studied using vivo microdialysis, concentration perfusate less than 50% that control increased levels treatment kainate were lower basal level rats, suggesting vesicular responsive deficiency. The glutamate more whereas GABA not at all unlike rats. results demonstrate an decrease as possible mechanism seizure under