An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits.
作者： Satoshi Takahashi , Levente Kapa´s , Jidong Fang , James M. Krueger
DOI: 10.1016/0006-8993(95)00609-T
关键词:
摘要: Abstract It is hypothesized that tumor necrosis factor (TNF) an endogenous sleep-promoting substance. In the present experiments we studied effects of a monoclonal anti-TNF antibody in rats and rabbits. Seven 14 rabbits were implanted with electroencephalographic electrodes, brain thermistor intracerebroventricular guide cannula. The animals injected saline, control IgG, hamster anti-murine-TNF antibodies (TNFab) on 3 separate days. Ten μg TNFab suppressed non-rapid-eye-movement sleep (NREMS) rats. rabbits, 2.5 did not affect but decreased temperature; contrast, 25 NREMS without affecting temperature. These results are consistent hypothesis TNF plays important role regulation.
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