Causes of death in multiple system atrophy
作者： S. Papapetropoulos , A. Tuchman , D. Laufer , A. G Papatsoris , N. Papapetropoulos
关键词:
摘要: Multiple system atrophy (MSA) is a heterogeneous neurodegenerative disorder, with clinical presentation combining extrapyramidal, cerebellar, autonomic or pyramidal symptoms. There are two major subtypes: MSA-P, predominance of parkinsonism, and MSA-C, cerebellar Although various factors have been proposed to predict survival in MSA, including age at onset several phenotypic features,1 the terminal/end life events never systematically studied. We present our results from study on causes death series pathologically confirmed, definite MSA cases. All patients registered University Miami/NPF Brain Endowment Bank (UM/BEB) donation programme diagnosis neuropathologically multiple (MSA; n = 21) were included this study. Pertinent information was gathered by prospectively filled questionnaires used as part UM/BEB’s recruitment process: (a) UM/BEB Parkinson’s disease registry form, 128-item, self-administered questionnaire demographics, environmental exposures, personal family history, comorbid conditions, activities daily living, treatment details; (b) “agonal state” 25-item covering 48 h before completed treating doctor/nurse. For comparisons, each case closely matched for (±2 years) sex brain donor an investigator blinded status information. Medical, hospital hospice …
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