Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain
作者： Rangarajan Parakalan , Boran Jiang , Baby Nimmi , Manivannan Janani , Manikandan Jayapal
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摘要: Background Microglia, the resident immune cells of central nervous system (CNS), have two distinct phenotypes in developing brain: amoeboid form, known to be microglial (AMC) and ramified (RMC). The AMC are characterized by being proliferative, phagocytic migratory whereas RMC quiescent exhibit a slow turnover rate. transform into with advancing age, this transformation is indicative gradual shift functions. Both respond CNS inflammation, they become hypertrophic when activated trauma, infection or neurodegenerative stimuli. molecular mechanisms functional significance morphological microglia during normal development disease conditions not clear. It hypothesized that functionally regulated specific set genes encoding various signaling molecules transcription factors.
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