Effect of eliminating intermittent white blood cells on immunology and cellular factors of systemic lupus erythematosus
作者： Lin-Fang Guo , Ruo-Hua Chen , Jin-Jin Jiang , Feng Fang
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摘要: Background: SLE is treated currently by multiple immunosuppression, but side-effects are obvious after long time administration. This study was to observe changes in T, B cells, NK cells and IL12 patients with systemic lupus erythematosus (SLE) before treatment of eliminating intermittent white blood probe the mechanism this treatment. Methods: In 23 SLE, 5 were male 18 female, an average age 15.78±5.40 years. These accepted cells. The expressions CD19 + , CD3 CD4 CD8 /CD8 CD(15+56) tested flow cytometry amounts immunoglobulins, IgM, IgG, IgA periphery measured separately immunoradiometric analysis level detected ELISA. Twenty volunteers served as controls. Results: expression increased markedly Statistical significance noted control group patient (P<0.01 or P<0.001). IgM IgG seen between activated (P<0.05) 0.001) respectively. decreased P<0.05) (P<0.001) ratio (P<0.01). more remarkably than (P<0.05). suggested that
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