Risk of acquiring multidrug-resistant Gram-negative bacilli from prior room occupants in the intensive care unit

摘要: The objective of this prospective cohort study was to determine whether admission an intensive care unit (ICU) room previously occupied by a patient with multidrug-resistant (MDR) Gram-negative bacilli (GNB) increases the risk acquiring these bacteria subsequent patients. All patients hospitalized for >48 h were eligible. Patients MDR GNB at ICU excluded. defined as Pseudomonas aeruginosa, Acinetobacter baumannii and extended spectrum β-lactamase (ESBL) -producing GNB. in single rooms. Cleaning rooms between two performed using quaternary ammonium disinfectant. Risk factors P. A. ESBL-producing determined univariate multivariate analysis. Five hundred eleven consecutive included; ICU-acquired aeruginosa diagnosed 82 (16%) patients, 57 (11%) 50 (9%) Independent prior occupant (OR 2.3, 95% CI 1.2-4.3, p 0.012), surgery 1.9, 1.1-3.6, 0.024), piperacillin/tazobactam use 1.2, 1.1-1.3, 0.040). 4.2, 2-8.8, <0.001), mechanical ventilation 9.3, 1.1-83, 0.045). tracheostomy 2.6, 1.1-6.5, 0.049), sedation 6.6, 1.1-40, 0.041). We conclude that or is independent factor acquisition occupants. This relationship not identified