Bone turnover and bone mineral density in young adult patients with panhypopituitarism before and after long-term growth hormone therapy.

摘要: We examined the effects of biosynthetic growth hormone (GH) on biochemical indices bone turnover and mineral density in a group GH-deficient adults. Thirteen patients (eight males five females) aged 24 +/- 5 years (range 16-35) were studied before 12 months after GH treatment (0.1 IU.kg-1 day-1, 6 days week). Serum levels insulin-like factor I (IGF-I), calcitonin, parathyroid hormone, alkaline phosphatase, intact osteocalcin, fasting urinary hydroxyproline/creatinine ratio (BMD), measured at lumbar spine by dual-photon absorptiometry, evaluated. After treatment, IGF-I, osteocalcin increased significantly. However, therapy, serum decreased to pretreatment values while phosphatase remained elevated No changes found calcitonin plasma or BMD either treatment. These data demonstrate that GH, dosage we used, activates during therapy adults with panhypopituitarism, even if downward trend for became apparent months. this activation was not accompanied an increase BMD. can hypothesize relatively high may stimulate osteoclastic activity greater extent than osteoblastic activity. It is probable dose replacement plays key role.