Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies

摘要: Thrombosis is a well-recognized complication following insertion of central venous catheters and associated with significant morbidity. In an attempt to reduce line-associated thrombosis, 108 consecutive patients haematological malignancies were commenced on prophylactic 'minidose' warfarin, 1 mg/d, at the time line insertion. This group compared historic 115 who had not received warfarin. Clinically-suspected thrombosis was confirmed by Doppler ultrasound or venography. Patients taking warfarin their prothrombin measured three times per week aim maintaining INR <1.6. Five (5%) minidose developed median 72 d (range 5-166) from catheter anticoagulated 15 (13%) catheter-associated 16 1-35). There reduction in receiving (P=0.03). These data suggest that reduces incidence related malignancies.