Impact of anesthesia and analgesia techniques on glioblastoma progression. A narrative review.

摘要: Glioblastoma (GBM) is an aggressive malignant CNS tumor with a median survival of 15 months after diagnosis. Standard therapy for GBM includes surgical resection, radiation, and temozolomide. Recently, anesthetics analgesics have received attention their potential involvement in mediating growth. This narrative review investigated whether various members the 2 aforementioned classes drugs definitive impact on progression by summarizing pertinent vitro, vivo, clinical studies. Recent publications regarding general been inconsistent, showing that they can be pro-tumoral or antitumoral depending experimental context. The local anesthetic lidocaine has shown consistent effects vitro. Clinical studies looking at not concluded use improves patient outcomes. In vitro vivo opioid demonstrated inconsistent findings these are antitumoral. Nonsteroidal anti-inflammatory drugs, specifically COX-2 inhibitors, across multiple beneficial halting progression. Until repeatable show suppress growth, there no strong evidence to recommend changes care patients.