Progressive alterations of cardiac hemodynamic and regional metabolic function after acute coronary occlusion.

摘要: Abstract Hemodynamic and regional metabolic function was assessed simultaneously in 34 closed chest dogs during a preocclusion control period 3 hours of intracoronary balloon occlusion the proximal left anterior descending artery. The data indicate immediate alteration hemodynamic measurements with many fluctuations hour period. No specific pattern evident. When mean were analyzed, found to cause early increases ventricular end-diastolic pressure (43 percent) systemic vascular resistance (21 percent), decreases peak systolic (5 maximal rate rise (dP/dt) (20 cardiac output (19 stroke work (26 coronary sinus blood flow percent). Regional showed significantly different occluded nonoccluded zones ventricle. Lactate balance decreased near production levels, substantial potassium loss occurred zone shortly after occlusion; lactate balances later fluctuated, but usually remained depressed. Abnormal metabolism efflux often observed zone. A 6 8 percent increase oxygen extraction noted both segments. Progressive alterations heart are not uniform exhibit dynamic fluctuations. Although direct relation between degree dysfunction change, individual experiments revealed distinct metabolic-mechanical dissociation.