Magnesium deficiency-induced osteoporosis in the rat: uncoupling of bone formation and bone resorption.

摘要: Magnesium (Mg) intake has been linked to bone mass and/or rate of loss in humans. Experimental Mg deficiency animal models resulted impaired growth, osteopenia, and increased skeletal fragility. In order assess changes mineral homeostasis that may be responsible, we induced dietary adult Simonsen albino rats for 16 weeks. Rats were fed either a low diet (0.002 percent) or normal control (0.063 percent). Blood was obtained at baseline, 4 weeks, 8 12 weeks both groups serum Mg, calcium, PTH, 1.25(OH)2-vitamin D determinations. Femora harvested analysis histomorphometry. Serum fell the depleted group 0.6 mg/dl (mean) by (controls = 2.0 mg/dl). The calcium (Ca) concentration higher animals 10.8 8.9 PTH progressively deficient 30 pg/ml week (control 96 pg/ml). also 14 While percent ash weights Ca phosphorus femur not different any time point, weight 0.54 vs (0.74 potassium approximately Histomorphometric analyses showed significant drop trabecular volume (percent BV/TV 13.2 17.3 controls). Evaluation endosteal surface features significantly greater resorption as reflected number tartrate-resistant positive osteoclasts/mm (7.8 4.0 controls) an elevated occupied osteoclasts OcS/BS 12.2 6.7 controls. This occurred presence inappropriate lowered forming relative controls; decreased osteoblasts per mm (0.23 0.94 control) decrease lined osteoid OS/BS 0.41 2.27 noted. Our findings demonstrate Mg-deficiency uncoupling formation resulting mass. fall 1.25(OH)2-D explain osteoblast activity, mechanism osteoclast activity is unclear. These data suggest risk factor osteoporosis.