Harnessing transposons for cancer gene discovery
作者： Neal G. Copeland , Nancy A. Jenkins
DOI: 10.1038/NRC2916
关键词:
摘要: Recently, it has become possible to mobilize the Tc1/mariner transposon, Sleeping Beauty (SB), in mouse somatic cells at frequencies high enough induce cancer. Tumours result from SB insertional mutagenesis of cancer genes, thus facilitating identification genes and signalling pathways that drive tumour formation. A conditional transposition system also been developed makes limit where occurs, providing a means selectively model many types human already identified large collection known addition plethora new candidate potential drug targets.
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