The histological spectrum of visceral leishmaniasis caused by Leishmania infantum MON-1 in acquired immune deficiency syndrome

摘要: Visceral leishmaniasis (VL) due to Leishmania infantum is endemic in Southern France and can be considered as an opportunistic infection patients with acquired immunodeficiency syndrome (AIDS). Co-infection sp. human virus (HIV) emerging, but pathological findings of AIDS have been poorly documented, scattered case reports include morphological descriptions. The clinicopathologic analysis 16 HIV VL were evaluated. clinical presentation was characteristic VL, fever, hepatosplenomegaly, pancytopenia 6 patients, the diagnosis confirmed by finding amastigotes bone marrow smears biopsy specimens. In 4 initial made fortuitously gastrointestinal biopsies performed systematically (3 patients) or diarrhea (1 patient). one duodenal biopsy, Mycobacteria associated. Liver allowed 3 cases. Autopsy 9 showing a disseminated very unusual localizations (adrenal heart) 2 Cutaneous involvement noted before (4 patients), at same time (2 patient), after patient) VL. Inflammatory infiltrates CD68 macrophages (8 without associated CD8 positive lymphocytes. Immunoperoxidase study using polyclonal anti- antibodies contributed all Electron microscopy digestive specimens showed ultrastructural characteristics amastigotes. zymodeme MON-1 L identified isoenzyme electrophoresis patients. mean CD4 counts 37/mm diagnosis, duration death 8 months. As shown this study, diagnosed liver biopsies. Diagnosis when count low correlated poor prognosis.