Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation
作者： Hugo Lavoie , David A Critton , Andrew Tebben , Anne Marinier , Frank Sicheri
DOI: 10.1038/NSMB.2924
关键词:
摘要: All RAF kinase domain structures reported to date have adopted a dimer configuration. Marc Therrien, Frank Sicheri and colleagues now report crystal structure of the BRAF monomeric 'off' state, providing insight into its catalytic activation.
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