THE BIOLOGY OF CANCER: METABOLIC REPROGRAMMING FUELS CELL GROWTH AND PROLIFERATION
作者： Ralph J. DeBerardinis , Julian J. Lum , Georgia Hatzivassiliou , Craig B. Thompson
DOI: 10.1016/J.CMET.2007.10.002
关键词:
摘要: Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider …
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